The bus crash happened at around 6am on Tuesday morning.
Baldwin County Sheriff’s Office Major Anthony Lowery said the charter bus crashed on Interstate 10 and plunged into a deep ravine.
At least 12 to 20 people have been injured in the crash near the Alabama and Florida state line.
It was carrying at least 52 people, WEAR-TV reports.
Officials said that there were multiple helicopters on the scene to help.
Local hospitals in Baldwin County are also standing by to help the injured.
Sheriff Huey Moss Mack said both lanes on the interstate have been closed.
Traffic has been diverted and Alabama State troopers are asking people to avoid the area.
The bus had been due to take the children back home to Channelview, Texas, in Houston.